The original strategic objective of my PhD researches in 1972-74 was to explore how primary kinetic hydrogen isotope effects might be influenced by the underlying structures of the transition state...
Read ItEarlier I explored models for the heteroaromatic electrophilic protiodecarboxylation of an 3-substituted indole, focusing on the role of water as the proton transfer and delivery agent. Next, came ...
Read ItThis is the third and final study deriving from my Ph.D.[1]. The first two topics dealt with the mechanism of heteroaromatic electrophilic attack using either a diazonium cation or a proton as elec...
Read ItAnother mechanistic study we started in 1972[1] is here 40+ years on subjected to quantum mechanical scrutiny. The kinetics are again complex, the mechanism involving protonation‡ of the...
Read ItThe BBC TV quiz series Mastermind was first broadcast in the UK in 1972, the same time I was starting to investigate the mechanism of diazocoupling to substituted indoles as part of my Ph.D. resear...
Read ItSource: Wikipedia. CC-BY-SA April this year I blogged about an important SPARQL query for many chemists: getting CAS registry numbers from Wikidata. This is relevant for two reasons: CAS works ...
Read It0000-0002-8635-8390 The science journal is generally acknowledged as first appearing around 1665 with the Philosophical Transactions of the Royal Society in London and (simultaneously) the French A...
Read ItThis is a talk I gave at the 5th Brazilian Conference on Natural Products as part of my “spare time” activities and to remain engaged with my passion of NMR, structure elucidation and computational...
Read It0000-0002-8635-8390 In 1953, the model of the DNA molecule led to what has become regarded as the most famous scientific diagram of the 20th century. It had all started 93 years earlier in 1860, at...
Read It0000-0002-8635-8390 The anomeric effect is best known in sugars, occuring in sub-structures such as RO-C-OR. Its origins relate to how the lone pairs on each oxygen atom align with the adjacent C-O...
Read ItAn article entitled " Four Decades of the Chemistry of Planar Hypercoordinate Compounds" was recently reviewed by Steve Bacharach on his blog, where you can also see comments. Given the recent crys...
Read It0000-0002-8635-8390 The previous post explored the structural features of amides. Here I compare the analysis with that for the closely related thioamides. Here is the torsional analysis around th...
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