Biogenic amines (BAs) are naturally present in various foods, and high levels of them have a negative impact on human health. Pichia kudriavzevii MZ5 exhibits excellent potential in degrading biogenic amines. Among the tested addition of the culture medium components, Mg2+ is the most effective factor of enhancing the ability of P. kudriavzevii MZ5 to degrade biogenic amines. After 72 h of cultivation, the total biogenic amines degradation rate increased from 14.2 % to 43.39 % when Mg2+presented in the medium. The biomass of P. kudriavzevii MZ5 decreased, but there was no correlation between the yeast biomass and the biogenic amines degradation rate in this experiment. The addition of Mg2+ in the medium increased the GSH of P. kudriavzevii MZ5 from 0.34 mg/mg prot to 0.82 mg/mg prot, GST from 2.76 U/mg prot to 3.30 U/mg prot, and Ca2+- Mg2+- ATPase activity from the original 5.36 U/mg prot to 17.36 U/mg prot. These results indicate that Mg2+ significate influenced the degradation ability of P. kudriavzevii MZ5 towards biogenic amines, which suggest that Mg2+ may have a great potential as a promoter for microbial degradation of biogenic amines.